Iron depletion: A defense against intracellular infection and neoplasia
Identifieur interne : 002E33 ( Main/Exploration ); précédent : 002E32; suivant : 002E34Iron depletion: A defense against intracellular infection and neoplasia
Auteurs : Eugene D. Weinberg [États-Unis]Source :
- Life Sciences [ 0024-3205 ] ; 1992.
English descriptors
- Teeft :
- Acad, Alveolar macrophages, Antibacterial action, Biol, Clin, Control cells, Different study, Endothelial cells, Hibbs, Host cells, Immune responses, Immunol, Intracellular, Intracellular growth, Iron content, Iron depletion, Iron depletion defense, Iron metabolism, Iron withholding, Large number, Macrophage, Murine, Natl, Neoplastic, Neoplastic cells, Nitric, Nitric oxide, Nitric oxide synthase, Other host cells, Oxide, Pathogen, Proc, Reactive, Reactive nitrogen, Reactive nitrogen intermediates, Stuehr, Synthase, Synthase activity, Tumor cells, Vertebrate hosts.
Abstract
Abstract: Macrophages and other host cells activated by interferon-γ (IFN-γ) can be induced to form a flavoprotein that converts L-arginine to nitric oxide + L-citrulline. Nitric oxide causes efflux of non-heme iron from neoplastic and infected host cells. In the absence of L-arginine, IFN-γ-induced infected cells can lower their net uptake of iron. Cellular depletion of the metal via either mechanism suppresses DNA synthesis as well as the functioning of aerobic respiratory enzymes. Macrophage regulation of growth of other host cells during embryogenesis, immune responses, or immunosurveillance might involve iron depletion.
Url:
DOI: 10.1016/0024-3205(92)90279-X
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002678
- to stream Istex, to step Curation: 002678
- to stream Istex, to step Checkpoint: 001C06
- to stream Main, to step Merge: 002E99
- to stream Main, to step Curation: 002E33
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Iron depletion: A defense against intracellular infection and neoplasia</title><author><name sortKey="Weinberg, Eugene D" sort="Weinberg, Eugene D" uniqKey="Weinberg E" first="Eugene D." last="Weinberg">Eugene D. Weinberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B6F6AC72790DC7D30901856BEB1C315C8B97BACF</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0024-3205(92)90279-X</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-HXQCXTCB-Z/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002678</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002678</idno><idno type="wicri:Area/Istex/Curation">002678</idno><idno type="wicri:Area/Istex/Checkpoint">001C06</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001C06</idno><idno type="wicri:doubleKey">0024-3205:1992:Weinberg E:iron:depletion:a</idno><idno type="wicri:Area/Main/Merge">002E99</idno><idno type="wicri:Area/Main/Curation">002E33</idno><idno type="wicri:Area/Main/Exploration">002E33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Iron depletion: A defense against intracellular infection and neoplasia</title><author><name sortKey="Weinberg, Eugene D" sort="Weinberg, Eugene D" uniqKey="Weinberg E" first="Eugene D." last="Weinberg">Eugene D. Weinberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Biology and Program in Medical Sciences, Indiana University, Bloomington</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">50</biblScope><biblScope unit="issue">18</biblScope><biblScope unit="page" from="1289">1289</biblScope><biblScope unit="page" to="1297">1297</biblScope></imprint><idno type="ISSN">0024-3205</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Alveolar macrophages</term><term>Antibacterial action</term><term>Biol</term><term>Clin</term><term>Control cells</term><term>Different study</term><term>Endothelial cells</term><term>Hibbs</term><term>Host cells</term><term>Immune responses</term><term>Immunol</term><term>Intracellular</term><term>Intracellular growth</term><term>Iron content</term><term>Iron depletion</term><term>Iron depletion defense</term><term>Iron metabolism</term><term>Iron withholding</term><term>Large number</term><term>Macrophage</term><term>Murine</term><term>Natl</term><term>Neoplastic</term><term>Neoplastic cells</term><term>Nitric</term><term>Nitric oxide</term><term>Nitric oxide synthase</term><term>Other host cells</term><term>Oxide</term><term>Pathogen</term><term>Proc</term><term>Reactive</term><term>Reactive nitrogen</term><term>Reactive nitrogen intermediates</term><term>Stuehr</term><term>Synthase</term><term>Synthase activity</term><term>Tumor cells</term><term>Vertebrate hosts</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Macrophages and other host cells activated by interferon-γ (IFN-γ) can be induced to form a flavoprotein that converts L-arginine to nitric oxide + L-citrulline. Nitric oxide causes efflux of non-heme iron from neoplastic and infected host cells. In the absence of L-arginine, IFN-γ-induced infected cells can lower their net uptake of iron. Cellular depletion of the metal via either mechanism suppresses DNA synthesis as well as the functioning of aerobic respiratory enzymes. Macrophage regulation of growth of other host cells during embryogenesis, immune responses, or immunosurveillance might involve iron depletion.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Indiana"><name sortKey="Weinberg, Eugene D" sort="Weinberg, Eugene D" uniqKey="Weinberg E" first="Eugene D." last="Weinberg">Eugene D. Weinberg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E33 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002E33 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B6F6AC72790DC7D30901856BEB1C315C8B97BACF
|texte= Iron depletion: A defense against intracellular infection and neoplasia
}}
| This area was generated with Dilib version V0.6.33. |  |